The RAPAd® method of Adenovirus construction,
developed by ViraQuest Inc. scientists, has been used by other
scientists around the world. Services, including RAPAd®, performed
by ViraQuest Inc. have been directly referenced by the following
publications:
Felty Q, Porther N. Atherosclerosis. Estrogen-induced redox sensitive Id3
signaling controls the growth of vascular cells. 2008 May;198(1):12-21. Epub 2008 Feb 20.
PubMed
Blasiole DA, Oler AT, Attie AD. Regulation of ApoB Secretion by the
Low Density Lipoprotein Receptor Requires Exit from the Endoplasmic
Reticulum and Interaction with ApoE or ApoB. J Biol Chem. 2008 Apr 25;283(17):11374-81.
Epub 2008 Feb 13.
PubMed
Casolaro V, Fang X, Tancowny B, Fan J, Wu F, Srikantan
S, Asaki SY, De Fanis U, Huang SK, Gorospe M, Atasoy UX, Stellato C. Posttranscriptional regulation of IL-13 in
T cells: role of the RNA-binding protein HuR. J Allergy Clin Immunol. 2008
Apr;121(4):853-9.e4. Epub 2008 Feb 14.
PubMed
Lo CY, Wu Z, Misplon JA, Price GE, Pappas C, Kong WP,
Tumpey TM, Epstein SL. Comparison of
vaccines for induction
of heterosubtypic immunity to influenza A virus: Cold-adapted vaccine
versus DNA prime-adenovirus boost strategies. Vaccine. 2008 Apr 16;26(17):2062-72. Epub
2008 Mar 13.
PubMed
Weydert CJ, Zhang Y, Sun W, Waugh TA, Teoh ML,
Andringa KK, Aykin-Burns N, Spitz DR, Smith BJ, Oberley LW. Increased oxidative stress created by
adenoviral MnSOD or CuZnSOD plus BCNU
(1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell
growth. Free Radic Biol Med.
2008 Mar 1;44(5):856-67. Epub 2007 Nov 28.
PubMed
Noor S, Goldfine H, Tucker DE, Suram S, Lenz LL, Akira
S, Uematsu S, Girotti M, Bonventre JV, Breuel K, Williams DL, Leslie
CC. Activation of cytosolic
phospholipase
A2alpha in resident peritoneal macrophages by Listeria monocytogenes
involves listeriolysin O and TLR2. J Biol Chem. 2008 Feb 22;283(8):4744-55.
Epub 2007 Dec 14.
PubMed
Hara-Chikuma M, Verkman AS. Aquaporin-3 facilitates epidermal cell
migration and proliferation during wound healing. Mol Med. 2008 Feb;86(2):221-31. Epub 2007
Oct 30.
PubMed
Galbán S, Kuwano Y, Pullmann R Jr, Martindale
JL, Kim HH, Lal A,
Abdelmohsen K, Yang X, Dang Y, Liu JO, Lewis SM, Holcik M, Gorospe M. RNA-binding proteins HuR and PTB promote
the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2008 Jan;28(1):93-107. Epub
2007 Oct 29.
PubMed
Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A,
Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR. Pulse inhibition of histone
deacetylases induces complete resistance to oxidative death in cortical
neurons without toxicity and reveals a role for cytoplasmic
p21(waf1/cip1) in cell cycle-independent neuroprotection. J Neurosci. 2008 Jan 2;28(1):163-76.
PubMed
Bell EL, Klimova TA, Eisenbart J,
Schumacker PT, Chandel NS. Mitochondrial
reactive oxygen species
trigger hypoxia-inducible factor-dependent extension of the replicative
life span during hypoxia. Mol
Cell Biol. 2007 Aug;27(16):5737-45. Epub 2007 Jun 11.
PubMed
Pochetuhen K, Luzina IG, Lockatell V,
Choi J, Todd NW, Atamas SP. Complex
regulation of pulmonary inflammation and fibrosis by CCL18. Am J Pathol. 2007 Aug;171(2):428-37. Epub
2007 Jun 14.
PubMed
Robin E, Guzy RD, Loor G, Iwase H,
Waypa GB, Marks JD, Hoek TL, Schumacker PT. Oxidant stress during simulated ischemia
primes cardiomyocytes for cell death during reperfusion. J Biol Chem. 2007 Jun 29;282(26):19133-43.
Epub 2007 May 7.
PubMed
Carè A, Catalucci D, Felicetti
F, Bonci D, Addario A, Gallo P, Bang ML,
Segnalini P, Gu Y, Dalton ND, Elia L, Latronico MV, Høydal M,
Autore C,
Russo MA, Dorn GW 2nd, Ellingsen O, Ruiz-Lozano P, Peterson KL, Croce
CM, Peschle C, Condorelli G. MicroRNA-133
controls cardiac hypertrophy. Nat
Med. 2007 May;13(5):613-8. Epub 2007 Apr 29.
PubMed
Chandler RJ, Tsai MS, Dorko K, Sloan
J, Korson M, Freeman R, Strom S, Venditti CP. Adenoviral-mediated correction of
methylmalonyl-CoA mutase deficiency in murine fibroblasts and human
hepatocytes. BMC Med Genet.
2007 Apr 30;8:24.
PubMed
Buckbinder L, Crawford DT, Qi H, Ke
HZ, Olson LM, Long KR, Bonnette PC,
Baumann AP, Hambor JE, Grasser WA 3rd, Pan LC, Owen TA, Luzzio MJ,
Hulford CA, Gebhard DF, Paralkar VM, Simmons HA, Kath JC, Roberts WG,
Smock SL, Guzman-Perez A, Brown TA, Li M. Proline-rich tyrosine kinase 2
regulates osteoprogenitor cells and bone formation, and offers an
anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A. 2007 Jun
19;104(25):10619-24. Epub 2007 May 30.
PubMed
Yao Y, Zebboudj AF, Torres A, Shao E,
Boström K. Activin-like kinase
receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal
cells. Cardiovasc Res. 2007
May 1;74(2):279-89. Epub 2006 Sep 27.
PubMed
Nassoury N, Blasiole DA, Oler AT,
Benjannet S, Hamelin J, Poupon V, McPherson PS, Attie AD, Prat A,
Seidah NG. The Cellular Trafficking
of the Secretory Proprotein Convertase PCSK9 and Its Dependence on the
LDLR. Traffic. 2007
Jul;8(7):950.
PubMed
Tompkins SM, Zhao ZS, Lo CY, Misplon
JA, Liu T, Ye Z, Hogan RJ, Wu Z, Benton KA, Tumpey TM, Epstein SL. Matrix protein 2 vaccination and
protection against influenza viruses, including subtype H5N1. Emerg Infect Dis. 2007 Mar;13(3):426-35.
PubMed
Zimmerman MC, Oberley LW, Flanagan
SW. Mutant SOD1-induced
neuronal toxicity is mediated by increased mitochondrial superoxide
levels. J Neurochem. 2007
Aug;102(3):609-18. Epub 2007 Mar 23.
PubMed
Huang Y, Wright CD, Merkwan CL, Baye
NL, Liang Q, Simpson PC, O'Connell TD. An
alpha1A-adrenergic-extracellular signal-regulated kinase survival
signaling pathway in cardiac myocytes. Circulation.
2007 Feb 13;115(6):763-72. Epub 2007 Feb 5.
PubMed
Wang Z, Oh E, Thurmond DC. Glucose-stimulated
Cdc42 signaling is essential for the second phase of insulin secretion.
J Biol Chem. 2007 Feb 8; [Epub ahead of print]
PubMed
Dankort D, Filenova E, Collado M,
Serrano M, Jones K, McMahon M. A new mouse model to explore the
initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes
Dev. 2007 Feb 15;21(4):379-84. Epub 2007 Feb 13.
PubMed
Schindler EM, Baumgartner M, Gribben
EM, Li L, Efimova T. The Role of Proline-Rich Protein Tyrosine
Kinase 2 in Differentiation-Dependent Signaling in Human Epidermal
Keratinocytes. J Invest Dermatol. 2007 Jan 4; [Epub
ahead of print]
PubMed
Zhou H, Li Z, Silver DL, Jiang XC. Cholesteryl
ester transfer protein
(CETP) expression enhances HDL cholesteryl ester liver delivery, which
is independent of scavenger receptor BI, LDL receptor related protein
and possibly LDL receptor. Biochim
Biophys Acta. 2006 Dec;1761(12):1482-8. Epub 2006 Sep 20.
PubMed
Muhle C, Neuner A, Park J, Pacho F,
Jiang Q, Waddington SN, Schneider H. Evaluation of prenatal
intra-amniotic LAMB3 gene delivery in a mouse model of Herlitz disease.
Gene Ther. 2006 Dec;13(23):1665-76. Epub
2006 Jul 27.
PubMed
Berasi SP, Huard C, Li D, Shih HH, Sun
Y, Zhong W, Paulsen JE, Brown EL, Gimeno RE, Martinez RV. Inhibition
of gluconeogenesis through transcriptional activation of EGR1 and DUSP
4 by AMPK. J Biol Chem. 2006 Sep 15;281(37):27167-77.
Epub Jul 18
PubMed
Proctor KM, Miller SC, Bryant NJ,
Gould GW. Syntaxin 16 controls the intracellular sequestration of
GLUT4 in 3T3-L1 adipocytes. Biochem Biophys Res Commun.
2006 Aug 25;347(2):433-8. Epub 2006 Jun 30.
PubMed
LaVallie ER, Chockalingam PS,
Collins-Racie LA, Freeman BA, Keohan CC, Leitges M, Dorner AJ, Morris
EA, Majumdar MK, Arai M. Protein kinase Czeta is up-regulated in
osteoarthritic cartilage and is required for activation of NF-kappaB by
tumor necrosis factor and interleukin-1 in articular chondrocytes. J
Biol Chem. 2006 Aug 25;281(34):24124-37. Epub 2006 Jun 23.
PubMed
Zhang Y, Smith BJ, Oberley LW. Enzymatic
activity is necessary for the tumor-suppressive effects of MnSOD. Antioxid
Redox Signal. 2006 Jul-Aug;8(7-8):1283-93.
PubMed
Luo J, Li L, Zhang Y, Spitz DR,
Buettner GR, Oberley LW, Domann FE. Inactivation of primary
antioxidant enzymes in mouse keratinocytes by photodynamically
generated singlet oxygen. Antioxid Redox Signal. 2006
Jul-Aug;8(7-8):1307-14.
PubMed
Weydert CJ, Waugh TA, Ritchie JM, Iyer
KS, Smith JL, Li L, Spitz DR, Oberley LW. Overexpression of
manganese or copper-zinc superoxide dismutase inhibits breast cancer
growth. Free Radic Biol Med. 2006 Jul 15;41(2):226-37.
Epub 2006 May 4.
PubMed
Luzina IG, Papadimitriou JC, Anderson
R, Pochetuhen K, Atamas SP. Induction of prolonged infiltration of
T lymphocytes and transient T lymphocyte-dependent collagen deposition
in mouse lungs following adenoviral gene transfer of CCL18. Arthritis
Rheum. 2006 Jul 25;54(8):2643-2655
PubMed
Nevins AK, Thurmond DC. Caveolin-1
Functions as a Novel Cdc42 Guanine Nucleotide Dissociation Inhibitor in
Pancreatic beta-Cells. J Biol Chem. 2006 Jul
14;281(28):18961-72. Epub 2006 May 19.
PubMed
Triplett JW, Pavalko F. Disruption
of {alpha}-Actinin-Integrin Interactions at Focal Adhesions Renders
Osteoblasts Susceptible to Apoptosis. Am J Physiol Cell
Physiol. 2006 Jun 28; [Epub ahead of print]
PubMed
Weydert CJ, Waugh TA, Ritchie JM, Iyer
KS, Smith JL, Li L, Spitz DR, Oberley LW. Overexpression of
manganese or copper-zinc superoxide dismutase inhibits breast cancer
growth. Free Radic Biol Med. 2006 Jul 15;41(2):226-37.
Epub 2006 May 4.
PubMed
Dong J, Liu J, Lou B, Li Z, Ye X, Wu
M, Jiang XC. Adenovirus-mediated overexpression of sphingomyelin
synthases 1 and 2 increases the atherogenic potential in mice. J
Lipid Res. 2006 Jun;47(6):1307-14. Epub 2006 Feb 28.
PubMed
Zhou J, Wu Y, Henderson F, McCoy DM,
Salome RG, McGowan SE, Mallampalli RK. Adenoviral gene transfer of
a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury.
Gene Ther. 2006 Jun;13(12):974-85. Epub
2006 Mar 2.
PubMed
Li W, Shen W, Gill R, Corbly A, Jones
B, Belagaje R, Zhang Y, Tang S, Chen Y, Zhai Y, Wang G, Wagle A, Hui K,
Westmore M, Hanson J, Chen YF, Simons M, Singh J. High-resolution
quantitative computed tomography demonstrating selective enhancement of
medium-size collaterals by placental growth factor-1 in the mouse
ischemic hindlimb. Circulation. 2006 May
23;113(20):2445-53. Epub 2006 May 15.
PubMed
Dwyer RM, Bergert ER, O'connor MK,
Gendler SJ, Morris JC. Adenovirus-Mediated and Targeted Expression
of the Sodium-Iodide Symporter Permits In Vivo Radioiodide Imaging and
Therapy of Pancreatic Tumors. Hum Gene Ther. 2006 May 15;
[Epub ahead of print]
PubMed
Niu G, Anderson RD, Madsen MT, Graham
MM, Oberley LW, Domann FE. Dual-expressing adenoviral vectors
encoding the sodium iodide symporter for use in noninvasive
radiological imaging of therapeutic gene transfer. Nucl
Med Biol. 2006 Apr;33(3):391-8.
PubMed
Davis CA, Haberland M, Arnold MA,
Sutherland LB, McDonald OG, Richardson JA, Childs G, Harris S, Owens
GK, Olson EN. PRISM/PRDM6, a Transcriptional Repressor That
Promotes the Proliferative Gene Program in Smooth Muscle Cells. Mol
Cell Biol. 2006 Apr;26(7):2626-36.
PubMed
Choudhury A, Marks DL, Proctor KM,
Gould GW, Pagano RE. Regulation of caveolar endocytosis by
syntaxin 6-dependent delivery of membrane components to the cell
surface. Nat Cell Biol. 2006 Apr;8(4):317-28. Epub 2006
Mar 26.
PubMed
Rachlin AS, Otey CA. Identification
of palladin isoforms and characterization of an isoform-specific
interaction between Lasp-1 and palladin. J Cell Sci. 2006
Mar 15;119(Pt 6):995-1004. Epub 2006 Feb 21.
PubMed
Trivedi AA, Igarashi T, Compagnone N,
Fan X, Hsu JY, Hall DE, John CM, Noble-Haeusslein LJ. Suitability
of allogeneic sertoli cells for ex vivo gene delivery in the injured
spinal cord. Exp Neurol. 2006 Mar;198(1):88-100.
PubMed
Tang Z, Sahu SN, Khadeer MA, Bai G,
Franklin RB, Gupta A. Overexpression of the ZIP1 zinc transporter
induces an osteogenic phenotype in mesenchymal stem cells. Bone.
2006 Feb;38(2):181-98. Epub 2005 Oct 3.
PubMed
Wolfrum C, Stoffel M. Coactivation
of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and
triglyceride/VLDL secretion. Cell Metab. 2006
Feb;3(2):99-110.
PubMed
Herve MA, Meduri G, Petit FG, Domet
TS, Lazennec G, Mourah S, Perrot-Applanat M. Regulation of the
vascular endothelial growth factor (VEGF) receptor Flk-1/KDR by
estradiol through VEGF in uterus. J Endocrinol. 2006
Jan;188(1):91-9.
PubMed
Dwyer RM, Bergert ER, O'connor MK,
Gendler SJ, Morris JC. Sodium iodide symporter-mediated
radioiodide imaging and therapy of ovarian tumor xenografts in mice.
Gene Ther. 2006 Jan;13(1):60-6.
PubMed
Liu J, Du J, Zhang Y, Sun W, Smith BJ,
Oberley LW, Cullen JJ. Suppression of the malignant phenotype in
pancreatic cancer by overexpression of phospholipid hydroperoxide
glutathione peroxidase. Hum Gene Ther. 2006
Jan;17(1):105-16.
PubMed
Xiong Z, Cheng Z, Zhang X, Patel M, Wu
JC, Gambhir SS, Chen X. Imaging Chemically Modified Adenovirus for
Targeting Tumors Expressing Integrin {alpha}v{beta}3 in Living Mice
with Mutant Herpes Simplex Virus Type 1 Thymidine Kinase PET Reporter
Gene. J Nucl Med. 2006 Jan;47(1):130-139.
PubMed
Karpova AY, Tervo DG, Gray NW, Svoboda
K. Rapid and reversible chemical inactivation of synaptic
transmission in genetically targeted neurons. Neuron.
2005 Dec 8;48(5):727-35.
PubMed
Wang M, Kirk JS, Venkataraman S,
Domann FE, Zhang HJ, Schafer FQ, Flanagan SW, Weydert CJ, Spitz DR,
Buettner GR, Oberley LW. Manganese superoxide dismutase suppresses
hypoxic induction of hypoxia-inducible factor-1alpha and vascular
endothelial growth factor. Oncogene. 2005 Dec
8;24(55):8154-66.
PubMed
Krutzfeldt J, Rajewsky N, Braich R,
Rajeev KG, Tuschl T, Manoharan M, Stoffel M. Silencing of
microRNAs in vivo with 'antagomirs'. Nature. 2005 Dec
1;438(7068):685-9. Epub 2005 Oct 30.
PubMed
Zhang X, Chen X, Song H, Chen HZ,
Rovin BH. Activation of the Nrf2/antioxidant response pathway
increases IL-8 expression. Eur J Immunol. 2005
Nov;35(11):3258-67.
PubMed
Kim A, Oberley LW, Oberley TD. Induction
of apoptosis by adenovirus-mediated manganese superoxide dismutase
overexpression in SV-40-transformed human fibroblasts. Free
Radic Biol Med. 2005 Nov 1;39(9):1128-41.
PubMed
Fielding AB, Schonteich E, Matheson J,
Wilson G, Yu X, Hickson GR, Srivastava S, Baldwin SA, Prekeris R, Gould
GW. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to
control membrane traffic in cytokinesis. EMBO J. 2005 Oct
5;24(19):3389-99. Epub 2005 Sep 8.
PubMed
Lee
VY, Schroedl C, Brunelle JK, Buccellato LJ, Akinci OI, Kaneto H, Snyder
C, Eisenbart J, Budinger GR, Chandel NS. Bleomycin induces
alveolar epithelial cell death through JNK-dependent activation of the
mitochondrial death pathway. Am J Physiol Lung Cell Mol
Physiol. 2005 Oct;289(4):L521-8.
PubMed
Khadeer MA, Sahu SN, Bai G, Abdulla S,
Gupta A. Expression of the zinc transporter ZIP1 in osteoclasts.
Bone. 2005 Sep;37(3):296-304.
PubMed
Lora JM, Zhang DM, Liao SM, Burwell T,
King AM, Barker PA, Singh L, Keaveney M, Morgenstern J, Gutierrez-Ramos
JC, Coyle AJ, Fraser CC.
TNF-alpha triggers mucus production in airway epithelium through an
IKKbeta dependent mechanism. J Biol Chem. 2005 Aug 25;
[Epub ahead of print]
PubMed
Wolfrum C, Poy MN, Stoffel M. Apolipoprotein
M is required for prebeta-HDL formation and cholesterol efflux to HDL
and protects against atherosclerosis. Nat Med. 2005
Apr;11(4):418-22. Epub 2005 Mar 27.
PubMed
Dwyer RM, Bergert ER, O'connor MK,
Gendler SJ, Morris JC. In vivo Radioiodide Imaging and Treatment
of Breast Cancer Xenografts after MUC1-Driven Expression of the Sodium
Iodide Symporter. Clin Cancer Res. 2005 Feb
15;11(4):1483-9.
PubMed
Scholz IV, Cengic N, Baker CH,
Harrington KJ, Maletz K, Bergert ER, Vile R, Göke B, Morris JC,
Spitzweg C. Radioiodine Therapy of Colon Cancer Follwing
Tissue-Specific Sodium Iodide Symporter Gene Transfer. Gene
Therapy 2005 Feb;12(3):272-80.
PubMed
Maxwell KN, Fisher EA, Breslow JL. Overexpression
of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic
reticulum compartment. Proc Natl Acad Sci U S A. 2005 Feb
8;102(6):2069-74.
PubMed
Jaruga-Killeen E, Rayford W. TNF
receptor 1 is involved in the induction of apoptosis by the
cyclin-dependent kinase inhibitor p27Kip1 in the prostate cancer cell
line PC-3. FASEB J. 2005 Jan;19(1):139-41.
PubMed
Wolfrum C, Asilmaz E, Luca E, Friedman
JM, Stoffel M. Foxa2 regulates lipid metabolism and ketogenesis in
the liver during fasting and in diabetes. Nature. 2004 Dec
23;432(7020):1027-32.
PubMed
He T, Peterson TE, Holmuhamedov EL,
Terzic A, Caplice NM, Oberley LW, Katusic ZS. Human endothelial
progenitor cells tolerate oxidative stress due to intrinsically high
expression of manganese superoxide dismutase. Arterioscler
Thromb Vasc Biol. 2004 Nov; 24(11):2021-7.
PubMed
Poy MN, Ellasson L, Krutzfeldt J,
Kuwajima S, Ma X, MacDonald PE, Pfeffer S, Tuschi T, Rajewsky N,
Rorsman P, Stoffel M. A Pancreatic islet-specific microRNA
regulates insulin secretion. Nature 2004 Nov 11; (432)
226-30.
PubMed
Meyerholz DK, Grubor B, Gallup JM
Lehmkuhl HD, Anderson RD, Lazic T, Ackermann MR. Adenovirus-mediated
Gene Therapy Enhances Parainfluenza Virus 3 Infection in Neonatal Lambs.
J. Clinical Microbiology 2004 Oct; 42(10):4780-7.
PubMed
Yamini B, Yu X, Gillespie GY, Kufe DW,
Weichselbaum RR. Transcriptional targeting of adenovirally
delivered tumor necrosis factor alpha by temozolomide in experimental
glioblastoma. Cancer Res. 2004 Sep 15;64(18):6381-4.
PubMed
Maxwell KN, Breslow JL. Adenoviral-mediated
expression of Pcsk-9 in mice results in a low-density lipoprotein
receptor knockout phenotype. PNAS 2004 May 4;
101(18):7100-5.
PubMed
Liu J, Hinkhouse MM, Sun W, Weydert
CJ, Ritchie JM, Oberley LW, Cullen JJ. Redox regulation of
pancreatic cancer cell growth: role of glutathione peroxidase in the
suppression of the malignant phenotype. Hum Gene Ther.
2004 Mar;15(3):239-50.
PubMed
Kardon G, Harfe BD, Tabin CJ. A
Tcf4-positive mesodermal population provides a prepattern for
vertebrate limb muscle patterning. Dev Cell. 2003
Dec;5(6):937-44.
PubMed
Kakinuma H, Bergert ER, Spitzweg C,
Cheville JC, Leiber MM, Morris, JC. Probasin Promoter
(ARR(2)PB)-Driven, Prostate-Specific Expression of the Human Sodium
Iodide Symporter (h-NIS) for Targeted Radioiodine Therapy of Prostate
Cancer. Cancer Research 2003 Nov 15; 63(22):7840-4.
PubMed
Wolfrum C, Shih DQ, Kuwajima S, Norris
AW, Kahn CR, Stoffel M. Role of Foxa-2 in adipocyte metabolism and
differentiation. J Clin Invest. 2003 Aug;112(3):345-56.
PubMed
