ViraQuest Inc. Innovative Adenovirus Technologies and Reagents
 

The RAPAd® method of Adenovirus construction, developed by ViraQuest Inc. scientists, has been used by other scientists around the world. Services, including RAPAd®, performed by ViraQuest Inc. have been directly referenced by the following publications:

 

Felty Q, Porther N. Atherosclerosis. Estrogen-induced redox sensitive Id3 signaling controls the growth of vascular cells. 2008 May;198(1):12-21. Epub 2008 Feb 20.
PubMed

Blasiole DA, Oler AT, Attie AD. Regulation of ApoB Secretion by the Low Density Lipoprotein Receptor Requires Exit from the Endoplasmic Reticulum and Interaction with ApoE or ApoB. J Biol Chem. 2008 Apr 25;283(17):11374-81. Epub 2008 Feb 13.
PubMed

Casolaro V, Fang X, Tancowny B, Fan J, Wu F, Srikantan S, Asaki SY, De Fanis U, Huang SK, Gorospe M, Atasoy UX, Stellato C. Posttranscriptional regulation of IL-13 in T cells: role of the RNA-binding protein HuR. J Allergy Clin Immunol. 2008 Apr;121(4):853-9.e4. Epub 2008 Feb 14.
PubMed

Lo CY, Wu Z, Misplon JA, Price GE, Pappas C, Kong WP, Tumpey TM, Epstein SL. Comparison of vaccines for induction of heterosubtypic immunity to influenza A virus: Cold-adapted vaccine versus DNA prime-adenovirus boost strategies. Vaccine. 2008 Apr 16;26(17):2062-72. Epub 2008 Mar 13.
PubMed

Weydert CJ, Zhang Y, Sun W, Waugh TA, Teoh ML, Andringa KK, Aykin-Burns N, Spitz DR, Smith BJ, Oberley LW. Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth. Free Radic Biol Med. 2008 Mar 1;44(5):856-67. Epub 2007 Nov 28.
PubMed

Noor S, Goldfine H, Tucker DE, Suram S, Lenz LL, Akira S, Uematsu S, Girotti M, Bonventre JV, Breuel K, Williams DL, Leslie CC. Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2. J Biol Chem. 2008 Feb 22;283(8):4744-55. Epub 2007 Dec 14.
PubMed

Hara-Chikuma M, Verkman AS. Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing. Mol Med. 2008 Feb;86(2):221-31. Epub 2007 Oct 30.
PubMed

Galbán S, Kuwano Y, Pullmann R Jr, Martindale JL, Kim HH, Lal A, Abdelmohsen K, Yang X, Dang Y, Liu JO, Lewis SM, Holcik M, Gorospe M. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2008 Jan;28(1):93-107. Epub 2007 Oct 29.
PubMed

Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR. Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection. J Neurosci. 2008 Jan 2;28(1):163-76.
PubMed

Bell EL, Klimova TA, Eisenbart J, Schumacker PT, Chandel NS. Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia. Mol Cell Biol. 2007 Aug;27(16):5737-45. Epub 2007 Jun 11.
PubMed

Pochetuhen K, Luzina IG, Lockatell V, Choi J, Todd NW, Atamas SP. Complex regulation of pulmonary inflammation and fibrosis by CCL18. Am J Pathol. 2007 Aug;171(2):428-37. Epub 2007 Jun 14.
PubMed

Robin E, Guzy RD, Loor G, Iwase H, Waypa GB, Marks JD, Hoek TL, Schumacker PT.  Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion. J Biol Chem. 2007 Jun 29;282(26):19133-43. Epub 2007 May 7.
PubMed

Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang ML, Segnalini P, Gu Y, Dalton ND, Elia L, Latronico MV, Høydal M, Autore C, Russo MA, Dorn GW 2nd, Ellingsen O, Ruiz-Lozano P, Peterson KL, Croce CM, Peschle C, Condorelli G. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007 May;13(5):613-8. Epub 2007 Apr 29.
PubMed

Chandler RJ, Tsai MS, Dorko K, Sloan J, Korson M, Freeman R, Strom S, Venditti CP. Adenoviral-mediated correction of methylmalonyl-CoA mutase deficiency in murine fibroblasts and human hepatocytes. BMC Med Genet. 2007 Apr 30;8:24.
PubMed

Buckbinder L, Crawford DT, Qi H, Ke HZ, Olson LM, Long KR, Bonnette PC, Baumann AP, Hambor JE, Grasser WA 3rd, Pan LC, Owen TA, Luzzio MJ, Hulford CA, Gebhard DF, Paralkar VM, Simmons HA, Kath JC, Roberts WG, Smock SL, Guzman-Perez A, Brown TA, Li M. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10619-24. Epub 2007 May 30.
PubMed

Yao Y, Zebboudj AF, Torres A, Shao E, Boström K. Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells. Cardiovasc Res. 2007 May 1;74(2):279-89. Epub 2006 Sep 27. 
PubMed

Nassoury N, Blasiole DA, Oler AT, Benjannet S, Hamelin J, Poupon V, McPherson PS, Attie AD, Prat A, Seidah NG. The Cellular Trafficking of the Secretory Proprotein Convertase PCSK9 and Its Dependence on the LDLR. Traffic. 2007 Jul;8(7):950.
PubMed

Tompkins SM, Zhao ZS, Lo CY, Misplon JA, Liu T, Ye Z, Hogan RJ, Wu Z, Benton KA, Tumpey TM, Epstein SL. Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1. Emerg Infect Dis. 2007 Mar;13(3):426-35.
PubMed

Zimmerman MC, Oberley LW, Flanagan SW.  Mutant SOD1-induced neuronal toxicity is mediated by increased mitochondrial superoxide levels. J Neurochem. 2007 Aug;102(3):609-18. Epub 2007 Mar 23.
PubMed

Huang Y, Wright CD, Merkwan CL, Baye NL, Liang Q, Simpson PC, O'Connell TD. An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation. 2007 Feb 13;115(6):763-72. Epub 2007 Feb 5.
PubMed

Wang Z, Oh E, Thurmond DC. Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion. J Biol Chem. 2007 Feb 8; [Epub ahead of print]
PubMed

Dankort D, Filenova E, Collado M, Serrano M, Jones K, McMahon M. A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev. 2007 Feb 15;21(4):379-84. Epub 2007 Feb 13.
PubMed

Schindler EM, Baumgartner M, Gribben EM, Li L, Efimova T. The Role of Proline-Rich Protein Tyrosine Kinase 2 in Differentiation-Dependent Signaling in Human Epidermal Keratinocytes. J Invest Dermatol. 2007 Jan 4; [Epub ahead of print]
PubMed

Zhou H, Li Z, Silver DL, Jiang XC. Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor. Biochim Biophys Acta. 2006 Dec;1761(12):1482-8. Epub 2006 Sep 20.
PubMed

Muhle C, Neuner A, Park J, Pacho F, Jiang Q, Waddington SN, Schneider H. Evaluation of prenatal intra-amniotic LAMB3 gene delivery in a mouse model of Herlitz disease. Gene Ther. 2006 Dec;13(23):1665-76. Epub 2006 Jul 27.
PubMed

Berasi SP, Huard C, Li D, Shih HH, Sun Y, Zhong W, Paulsen JE, Brown EL, Gimeno RE, Martinez RV. Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP 4 by AMPK. J Biol Chem. 2006 Sep 15;281(37):27167-77. Epub Jul 18
PubMed

Proctor KM, Miller SC, Bryant NJ, Gould GW. Syntaxin 16 controls the intracellular sequestration of GLUT4 in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2006 Aug 25;347(2):433-8. Epub 2006 Jun 30.
PubMed

LaVallie ER, Chockalingam PS, Collins-Racie LA, Freeman BA, Keohan CC, Leitges M, Dorner AJ, Morris EA, Majumdar MK, Arai M. Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes. J Biol Chem. 2006 Aug 25;281(34):24124-37. Epub 2006 Jun 23.
PubMed

Zhang Y, Smith BJ, Oberley LW. Enzymatic activity is necessary for the tumor-suppressive effects of MnSOD. Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1283-93.
PubMed

Luo J, Li L, Zhang Y, Spitz DR, Buettner GR, Oberley LW, Domann FE. Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen. Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1307-14.
PubMed

Weydert CJ, Waugh TA, Ritchie JM, Iyer KS, Smith JL, Li L, Spitz DR, Oberley LW. Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth. Free Radic Biol Med. 2006 Jul 15;41(2):226-37. Epub 2006 May 4.
PubMed

Luzina IG, Papadimitriou JC, Anderson R, Pochetuhen K, Atamas SP. Induction of prolonged infiltration of T lymphocytes and transient T lymphocyte-dependent collagen deposition in mouse lungs following adenoviral gene transfer of CCL18. Arthritis Rheum. 2006 Jul 25;54(8):2643-2655
PubMed

Nevins AK, Thurmond DC. Caveolin-1 Functions as a Novel Cdc42 Guanine Nucleotide Dissociation Inhibitor in Pancreatic beta-Cells. J Biol Chem. 2006 Jul 14;281(28):18961-72. Epub 2006 May 19.
PubMed

Triplett JW, Pavalko F. Disruption of {alpha}-Actinin-Integrin Interactions at Focal Adhesions Renders Osteoblasts Susceptible to Apoptosis. Am J Physiol Cell Physiol. 2006 Jun 28; [Epub ahead of print]
PubMed

Weydert CJ, Waugh TA, Ritchie JM, Iyer KS, Smith JL, Li L, Spitz DR, Oberley LW. Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth. Free Radic Biol Med. 2006 Jul 15;41(2):226-37. Epub 2006 May 4.
PubMed

Dong J, Liu J, Lou B, Li Z, Ye X, Wu M, Jiang XC. Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice. J Lipid Res. 2006 Jun;47(6):1307-14. Epub 2006 Feb 28.
PubMed

Zhou J, Wu Y, Henderson F, McCoy DM, Salome RG, McGowan SE, Mallampalli RK. Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury. Gene Ther. 2006 Jun;13(12):974-85. Epub 2006 Mar 2.
PubMed

Li W, Shen W, Gill R, Corbly A, Jones B, Belagaje R, Zhang Y, Tang S, Chen Y, Zhai Y, Wang G, Wagle A, Hui K, Westmore M, Hanson J, Chen YF, Simons M, Singh J. High-resolution quantitative computed tomography demonstrating selective enhancement of medium-size collaterals by placental growth factor-1 in the mouse ischemic hindlimb. Circulation. 2006 May 23;113(20):2445-53. Epub 2006 May 15.
PubMed

Dwyer RM, Bergert ER, O'connor MK, Gendler SJ, Morris JC. Adenovirus-Mediated and Targeted Expression of the Sodium-Iodide Symporter Permits In Vivo Radioiodide Imaging and Therapy of Pancreatic Tumors. Hum Gene Ther. 2006 May 15; [Epub ahead of print]
PubMed

Niu G, Anderson RD, Madsen MT, Graham MM, Oberley LW, Domann FE. Dual-expressing adenoviral vectors encoding the sodium iodide symporter for use in noninvasive radiological imaging of therapeutic gene transfer. Nucl Med Biol. 2006 Apr;33(3):391-8.
PubMed

Davis CA, Haberland M, Arnold MA, Sutherland LB, McDonald OG, Richardson JA, Childs G, Harris S, Owens GK, Olson EN. PRISM/PRDM6, a Transcriptional Repressor That Promotes the Proliferative Gene Program in Smooth Muscle Cells. Mol Cell Biol. 2006 Apr;26(7):2626-36.
PubMed

Choudhury A, Marks DL, Proctor KM, Gould GW, Pagano RE. Regulation of caveolar endocytosis by syntaxin 6-dependent delivery of membrane components to the cell surface. Nat Cell Biol. 2006 Apr;8(4):317-28. Epub 2006 Mar 26.
PubMed

Rachlin AS, Otey CA. Identification of palladin isoforms and characterization of an isoform-specific interaction between Lasp-1 and palladin. J Cell Sci. 2006 Mar 15;119(Pt 6):995-1004. Epub 2006 Feb 21.
PubMed

Trivedi AA, Igarashi T, Compagnone N, Fan X, Hsu JY, Hall DE, John CM, Noble-Haeusslein LJ. Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord. Exp Neurol. 2006 Mar;198(1):88-100.
PubMed

Tang Z, Sahu SN, Khadeer MA, Bai G, Franklin RB, Gupta A. Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells. Bone. 2006 Feb;38(2):181-98. Epub 2005 Oct 3.
PubMed

Wolfrum C, Stoffel M. Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metab. 2006 Feb;3(2):99-110.
PubMed

Herve MA, Meduri G, Petit FG, Domet TS, Lazennec G, Mourah S, Perrot-Applanat M. Regulation of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR by estradiol through VEGF in uterus. J Endocrinol. 2006 Jan;188(1):91-9.
PubMed

Dwyer RM, Bergert ER, O'connor MK, Gendler SJ, Morris JC. Sodium iodide symporter-mediated radioiodide imaging and therapy of ovarian tumor xenografts in mice. Gene Ther. 2006 Jan;13(1):60-6.
PubMed

Liu J, Du J, Zhang Y, Sun W, Smith BJ, Oberley LW, Cullen JJ. Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase. Hum Gene Ther. 2006 Jan;17(1):105-16.
PubMed

Xiong Z, Cheng Z, Zhang X, Patel M, Wu JC, Gambhir SS, Chen X. Imaging Chemically Modified Adenovirus for Targeting Tumors Expressing Integrin {alpha}v{beta}3 in Living Mice with Mutant Herpes Simplex Virus Type 1 Thymidine Kinase PET Reporter Gene. J Nucl Med. 2006 Jan;47(1):130-139.
PubMed

Karpova AY, Tervo DG, Gray NW, Svoboda K. Rapid and reversible chemical inactivation of synaptic transmission in genetically targeted neurons. Neuron. 2005 Dec 8;48(5):727-35.
PubMed

Wang M, Kirk JS, Venkataraman S, Domann FE, Zhang HJ, Schafer FQ, Flanagan SW, Weydert CJ, Spitz DR, Buettner GR, Oberley LW. Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Oncogene. 2005 Dec 8;24(55):8154-66.
PubMed

Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M. Silencing of microRNAs in vivo with 'antagomirs'. Nature. 2005 Dec 1;438(7068):685-9. Epub 2005 Oct 30.
PubMed

Zhang X, Chen X, Song H, Chen HZ, Rovin BH. Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. Eur J Immunol. 2005 Nov;35(11):3258-67.
PubMed

Kim A, Oberley LW, Oberley TD. Induction of apoptosis by adenovirus-mediated manganese superoxide dismutase overexpression in SV-40-transformed human fibroblasts. Free Radic Biol Med. 2005 Nov 1;39(9):1128-41.
PubMed

Fielding AB, Schonteich E, Matheson J, Wilson G, Yu X, Hickson GR, Srivastava S, Baldwin SA, Prekeris R, Gould GW. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J. 2005 Oct 5;24(19):3389-99. Epub 2005 Sep 8.
PubMed

Lee VY, Schroedl C, Brunelle JK, Buccellato LJ, Akinci OI, Kaneto H, Snyder C, Eisenbart J, Budinger GR, Chandel NS. Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway. Am J Physiol Lung Cell Mol Physiol. 2005 Oct;289(4):L521-8.
PubMed

Khadeer MA, Sahu SN, Bai G, Abdulla S, Gupta A. Expression of the zinc transporter ZIP1 in osteoclasts. Bone. 2005 Sep;37(3):296-304.
PubMed

Lora JM, Zhang DM, Liao SM, Burwell T, King AM, Barker PA, Singh L, Keaveney M, Morgenstern J, Gutierrez-Ramos JC, Coyle AJ, Fraser CC.
TNF-alpha triggers mucus production in airway epithelium through an IKKbeta dependent mechanism.
J Biol Chem. 2005 Aug 25; [Epub ahead of print]
PubMed

Wolfrum C, Poy MN, Stoffel M. Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med. 2005 Apr;11(4):418-22. Epub 2005 Mar 27.
PubMed

Dwyer RM, Bergert ER, O'connor MK, Gendler SJ, Morris JC. In vivo Radioiodide Imaging and Treatment of Breast Cancer Xenografts after MUC1-Driven Expression of the Sodium Iodide Symporter. Clin Cancer Res. 2005 Feb 15;11(4):1483-9.
PubMed

Scholz IV, Cengic N, Baker CH, Harrington KJ, Maletz K, Bergert ER, Vile R, Göke B, Morris JC, Spitzweg C. Radioiodine Therapy of Colon Cancer Follwing Tissue-Specific Sodium Iodide Symporter Gene Transfer. Gene Therapy 2005 Feb;12(3):272-80.
PubMed

Maxwell KN, Fisher EA, Breslow JL. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2069-74.
PubMed

Jaruga-Killeen E, Rayford W. TNF receptor 1 is involved in the induction of apoptosis by the cyclin-dependent kinase inhibitor p27Kip1 in the prostate cancer cell line PC-3. FASEB J. 2005 Jan;19(1):139-41.
PubMed

Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature. 2004 Dec 23;432(7020):1027-32.
PubMed

He T, Peterson TE, Holmuhamedov EL, Terzic A, Caplice NM, Oberley LW, Katusic ZS. Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase. Arterioscler Thromb Vasc Biol. 2004 Nov; 24(11):2021-7.
PubMed

Poy MN, Ellasson L, Krutzfeldt J, Kuwajima S, Ma X, MacDonald PE, Pfeffer S, Tuschi T, Rajewsky N, Rorsman P, Stoffel M. A Pancreatic islet-specific microRNA regulates insulin secretion. Nature 2004 Nov 11; (432) 226-30.
PubMed

Meyerholz DK, Grubor B, Gallup JM Lehmkuhl HD, Anderson RD, Lazic T, Ackermann MR. Adenovirus-mediated Gene Therapy Enhances Parainfluenza Virus 3 Infection in Neonatal Lambs. J. Clinical Microbiology 2004 Oct; 42(10):4780-7.
PubMed

Yamini B, Yu X, Gillespie GY, Kufe DW, Weichselbaum RR. Transcriptional targeting of adenovirally delivered tumor necrosis factor alpha by temozolomide in experimental glioblastoma. Cancer Res. 2004 Sep 15;64(18):6381-4.
PubMed

Maxwell KN, Breslow JL. Adenoviral-mediated expression of Pcsk-9 in mice results in a low-density lipoprotein receptor knockout phenotype. PNAS 2004 May 4; 101(18):7100-5.
PubMed

Liu J, Hinkhouse MM, Sun W, Weydert CJ, Ritchie JM, Oberley LW, Cullen JJ. Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype. Hum Gene Ther. 2004 Mar;15(3):239-50.
PubMed

Kardon G, Harfe BD, Tabin CJ. A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning. Dev Cell. 2003 Dec;5(6):937-44.
PubMed

Kakinuma H, Bergert ER, Spitzweg C, Cheville JC, Leiber MM, Morris, JC. Probasin Promoter (ARR(2)PB)-Driven, Prostate-Specific Expression of the Human Sodium Iodide Symporter (h-NIS) for Targeted Radioiodine Therapy of Prostate Cancer. Cancer Research 2003 Nov 15; 63(22):7840-4.
PubMed

Wolfrum C, Shih DQ, Kuwajima S, Norris AW, Kahn CR, Stoffel M. Role of Foxa-2 in adipocyte metabolism and differentiation. J Clin Invest. 2003 Aug;112(3):345-56.
PubMed

 

 

 

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